| PBPKO:03013 |
effective Caco-2 permeability |
A biochemical parameter representing the corrected rate constant of compound movement across a Caco-2 cell monolayer.
|
|
| PBPKO:00517 |
mammary gland plasma partition coefficient |
A partition coefficient representing the ratio of compound concentration in the mammary gland to plasma.
|
mam plasma pc
|
| PBPKO:00230 |
fecal clearance rate |
A clearance rate specifically quantifying elimination via feces.
|
|
| PBPKO:06024 |
unbound venous fat concentration |
The unbound venous concentration of compound in the fat compartment.
|
cvfat_unbound
|
| PBPKO:00575 |
kidney blood partition coefficient |
A partition coefficient representing the ratio of compound concentration in the kidney to blood.
|
kidney blood pc
|
| PBPKO:00639 |
amount in skin stratum corneum of unexposed skin |
The amount of chemical in skin stratum corneum of unexposed skin
|
askin_sc_u
|
| PBPKO:00007 |
body mass index |
A physiological parameter calculated as an individual's weight (kg) divided by the square of their height (m).
|
BMI
|
| PBPKO:03055 |
cell fraction of mitochondria |
|
|
| PBPKO:00363 |
hippocampus brain partition coefficient |
A partition coefficient representing the ratio of compound concentration in the hippocampus to the overall brain.
|
hippocampus brain pc
|
| PBPKO:03063 |
plate wall thickness |
|
|
| PBPKO:00253 |
peak concentration |
An output parameter representing the highest concentration (Cmax) of a compound achieved after exposure.
|
Cmax
|
| PBPKO:03052 |
cell fraction of proteins |
|
|
| PBPKO:00183 |
air plasma partition coefficient |
A partition coefficient representing the ratio of compound concentration in air to plasma.
|
air plasma pc
|
| PBPKO:00386 |
blood flow rate to restbody fetus |
A blood flow rate parameter specifically describing the rate to the rest of body compartment within the fetus.
|
qrestbodyfetus
|
| PBPKO:00415 |
blood flow rate to jejunum |
A blood flow rate parameter specifically describing the rate to the jejunum compartment.
|
qjejunum
|
| PBPKO:00061 |
fraction of exposed skin |
A dimensionless fraction of volume defined as the exposed skin volume divided per unit of total body weight.
|
fskin e
|
| PBPKO:03018 |
intrinsic absorption rate of metabilite |
A biochemical parameter representing the rate constant of absorption of a metabolic product.
|
|
| PBPKO:00550 |
amount in fat |
The amount of compound in the fat compartment.
|
afat
|
| PBPKO:03045 |
abiotic degradation rate in medium |
|
|
| PBPKO:06015 |
amount in intestinal tissue |
The amount of chemical in intestinal tissue
|
ait
|
| PBPKO:04045 |
blood flow rate to bile |
|
|
| PBPKO:00047 |
fraction of blood flow to poorly perfused |
The dimensionless fraction of cardiac output delivered to the poorly perfused compartment.
|
fqpoorlyperfused
|
| PBPKO:00279 |
min organ concentration |
An output parameter representing the minimum concentration of a compound in a specific organ after exposure.
|
|
| PBPKO:00062 |
fraction of unexposed skin |
A dimensionless fraction of volume defined as the unexposed skin volume divided per unit of total body weight.
|
fskin u
|
| PBPKO:00376 |
volume of liver fetus |
A volume parameter representing the total volume of the fetal liver compartment.
|
vliver fetus
|
| PBPKO:06054 |
concentration in medium |
|
|
| PBPKO:00536 |
resorption |
A biochemical parameter or process representing the resorption of a compound (e.g., tubular resorption).
|
tm
|
| PBPKO:04077 |
volume of urinary tract |
|
|
| PBPKO:00088 |
fraction of gonad |
A dimensionless fraction of volume defined as the gonad volume divided per unit of total body weight.
|
fgonad
|
| PBPKO:00263 |
bioavailability |
An output parameter representing the rate and extent to which an active compound is absorbed and becomes available at the site of action or systemic circulation.
|
f
|
| PBPKO:00531 |
blood flow rate to gut |
A blood flow rate parameter specifically describing the rate to the gut compartment.
|
qgut
|
| PBPKO:04072 |
volume of gut intestinal tract |
|
|
| PBPKO:03058 |
fraction of neutral lipids in the FBS |
|
|
| PBPKO:00099 |
volume of poorly perfused |
A volume parameter representing the total volume of the poorly perfused compartment.
|
vpoorly perfused
|
| PBPKO:00160 |
fraction unbound skin |
An unbound fraction parameter specifically for the skin compartment.
|
fuskin
|
| PBPKO:00037 |
fraction of blood flow to skin |
The dimensionless fraction of cardiac output delivered to the skin compartment.
|
fqskin
|
| PBPKO:00514 |
fraction of blood flow to mammary gland |
The dimensionless fraction of cardiac output delivered to the mammary gland compartment.
|
fqmam
|
| PBPKO:00648 |
diffusion rate stratum corneum viable epidermis |
A diffusion rate skin parameter representing diffusion rate from stratum corneum to viable epidermis
|
kp_sc_vs
|
| PBPKO:00243 |
intravenous bolus exposure |
A route of exposure involving rapid injection directly into a vein.
|
IVB
|
| PBPKO:00378 |
volume of kidney fetus |
A volume parameter representing the total volume of the fetal kidney compartment.
|
vkidneyfetus
|
| PBPKO:00367 |
apparent permeability cerebrum to rest of brain |
Apparent permeability of a compound specifically between the cerebrum and the rest of the brain.
|
papp cerebrum brain
|
| PBPKO:00500 |
amount in delay |
The amount of compound in the hypothetical delay compartment.
|
adelay
|
| PBPKO:06006 |
amount in jejunum |
The amount of chemical in jejunum compartment.
|
aj
|
| PBPKO:03015 |
kinetic emptying rate between intestinal segments |
A biochemical parameter representing the generalized transit rate constant between adjacent sections of the gastrointestinal tract.
|
|
| PBPKO:00574 |
intestine blood partition coefficient |
A partition coefficient representing the ratio of compound concentration in the intestine to blood.
|
intestine blood pc
|
| PBPKO:00249 |
nasal exposure |
A route of exposure via the nasal passages.
|
|
| PBPKO:00025 |
fraction of blood flow to liver |
The dimensionless fraction of cardiac output delivered to the liver compartment.
|
fqliver
|
| PBPKO:00071 |
volume of small intestine |
A volume parameter representing the total volume of the small intestine compartment.
|
vsmall intestine
|
| PBPKO:00064 |
venous blood flow rate |
A blood flow rate parameter representing the rate of blood flow returning through the venous compartment.
|
|
| PBPKO:00651 |
fraction of arterial blood volume |
A dimensionless fraction of volume defined as the arterial blood volume divided per unit of total body weight.
|
farterialblood
scvart
|
| PBPKO:03050 |
cell radius |
|
|
| PBPKO:00508 |
fraction of filtrate |
A dimensionless fraction of volume defined as the filtrate volume divided per unit of total body weight.
|
ffiltrate
|
| PBPKO:04035 |
plasma flow rate to exposed skin |
A plasma flow rate parameter specifically describing the rate to the exposed skin compartment.
|
qskine_p
|
| PBPKO:00644 |
thickness viable epidermis |
A skin thickness parameter representing the thickness of viable epidermis.
|
height_vs
thickness_ve
|
| PBPKO:00365 |
cerebellum brain partition coefficient |
A partition coefficient representing the ratio of compound concentration in the cerebellum to the overall brain.
|
cerebellum brain pc
|
| PBPKO:00504 |
amount in lung |
The amount of compound in the lung compartment.
|
alung
|
| PBPKO:00359 |
blood flow rate to hippocampus |
A blood flow rate parameter specifically describing the rate to the hippocampus compartment.
|
qhippocampus
|
| PBPKO:00299 |
concentration in nail |
A biological matrix concentration specifically representing the total concentration of compound in the nail compartment.
|
cnail
|
| PBPKO:04093 |
fraction of skeleton |
A fraction of volume of compartment defined as the skeleton volume divided per unit of total body weight.
|
|
| PBPKO:00120 |
fraction of lymph |
A dimensionless fraction of volume defined as the lymph volume divided per unit of total body weight.
|
flymph
|
| PBPKO:00503 |
amount in brain |
The amount of compound in the brain compartment.
|
abrain
|
| PBPKO:06042 |
concentration in small intestine |
The concentration of chemical in small intestine compartment.
|
csi
|
| PBPKO:00635 |
skin thickness |
A physiological parameter representing the thickness of the skin compartment
|
|
| PBPKO:00641 |
dermal absorption rate unexposed skin |
An absorption rate constant parameter representing dermal absorption rate flux through unexposed skin
|
fs_u
|
| PBPKO:04062 |
volume of follicle |
A volume of compartment representing the total volume of hair follicles.
|
|
| PBPKO:06018 |
unbound venous liver concentration |
The unbound venous concentration of compound in the liver compartment.
|
cvliver_unbound
|
| PBPKO:00433 |
particle radius |
A biochemical/physical parameter representing the radius of particles (e.g., of the administered compound).
|
|
| PBPKO:00425 |
volume of jejunum |
A volume parameter representing the total volume of the jejunum compartment.
|
vjejunum
|
| PBPKO:00388 |
gestational week |
A physiological parameter representing the specific week of gestation.
|
gw
|
| PBPKO:00115 |
volume of gall bladder |
A volume parameter representing the total volume of the gall bladder compartment.
|
vgall bladder
|
| PBPKO:00011 |
assigned race |
A parameter representing a geographic ancestral origin category assigned to a population group.
|
|
| PBPKO:04034 |
plasma flow rate to unexposed skin |
A plasma flow rate parameter specifically describing the rate to the unexposed skin compartment.
|
|
| PBPKO:00281 |
median organ concentration |
An output parameter representing the median concentration of a compound in a specific organ after exposure.
|
|
| PBPKO:04050 |
surface area of the jejunum lumen |
|
|
| PBPKO:00362 |
blood flow rate to cerebellum |
A blood flow rate parameter specifically describing the rate to the cerebellum compartment.
|
qcerebellum
|
| PBPKO:03021 |
enterohepatic recirculation rate constant |
A biochemical parameter representing the allometrically scaled rate constant for the recycling process between liver, bile, and intestine (dependent on species).
|
|
| PBPKO:03047 |
abiotic degradation rate in air |
|
|
| PBPKO:00067 |
volume of stomach |
A volume parameter representing the total volume of the stomach compartment.
|
vstomach
|
| PBPKO:00357 |
volume of cerebrum |
A volume parameter representing the total volume of the cerebrum compartment.
|
vcerebrum
|
| PBPKO:00237 |
renal elimination rate constant |
A biochemical parameter representing the rate constant for elimination via renal (urinary) excretion.
|
|
| PBPKO:04076 |
volume of hair |
|
|
| PBPKO:00080 |
fraction of kidney |
A dimensionless fraction of volume defined as the kidney volume divided per unit of total body weight.
|
fkidney
|
| PBPKO:06028 |
unbound venous rest body concentration |
The unbound venous concentration of compound in the rest body compartment.
|
cvrestbody_unbound
|
| PBPKO:00364 |
cerebrum brain partition coefficient |
A partition coefficient representing the ratio of compound concentration in the cerebrum to the overall brain.
|
cerebrum brain pc
|
| PBPKO:00334 |
infant lifestage |
A lifestage parameter representing a very young child, typically under one year of age.
|
Inf
|
| PBPKO:00128 |
lipophillicity |
A physicochemical parameter representing the affinity or tendency of a compound to dissolve in lipids or hydrophobic environments.
|
|
| PBPKO:00178 |
spleen plasma partition coefficient |
A partition coefficient representing the ratio of compound concentration in spleen to plasma.
|
spleen plasma pc
|
| PBPKO:06003 |
unbound concentration of compund in compartment |
|
|
| PBPKO:04017 |
plasma flow rate to lung |
A plasma flow rate parameter specifically describing the rate to the lung compartment.
|
|
| PBPKO:00251 |
ocular exposure |
A route of exposure via the eye.
|
|
| PBPKO:00569 |
brain blood partition coefficient |
A partition coefficient representing the ratio of compound concentration in brain to blood.
|
brain blood pc
|
| PBPKO:04046 |
diameter of intestinal |
|
|
| PBPKO:00045 |
fraction of blood flow to lung |
The dimensionless fraction of cardiac output delivered to the lung compartment.
|
fqlung
|
| PBPKO:03036 |
octanol water partition coefficient |
|
|
| PBPKO:00020 |
blood flow rate to large intestine |
A blood flow rate parameter specifically describing the rate to the large intestine compartment.
|
qlargeintestine
|
| PBPKO:00093 |
volume of brain |
A volume parameter representing the total volume of the brain compartment.
|
vbrain
|
| PBPKO:00419 |
fraction of duodenum |
A dimensionless fraction of volume defined as the duodenum volume divided per unit of total body weight.
|
fduodenum
|
| PBPKO:04001 |
plasma flow rate |
A bodily fluid flow rate parameter specifically describing the flow of plasma to a compartment.
|
qplasma
|
| PBPKO:00593 |
maximum rate of basolateral transporter |
Maximum rate (Vmax) of transport via a basolateral transporter.
|
vmax baso
|
| PBPKO:04078 |
volume of skin surface depot |
|
|
| PBPKO:00180 |
rich perfused plasma partition coefficient |
A partition coefficient representing the ratio of compound concentration in the lumped richly perfused compartment to plasma.
|
rich perfused plasma pc
|
| PBPKO:00509 |
fraction of gut |
A dimensionless fraction of volume defined as the gut volume divided per unit of total body weight.
|
fgut
|
| PBPKO:06014 |
amount in duodenum |
The amount of chemical in duodenum compartment.
|
aduo
|
| PBPKO:03019 |
absorption rate of metabolite |
A biochemical parameter representing the allometrically scaled rate constant of absorption at which a metabolite is absorbed into systemic circulation (dependent on species).
|
|
| PBPKO:00577 |
liver blood partition coefficient |
A partition coefficient representing the ratio of compound concentration in the liver to blood.
|
liver blood pc
|
| PBPKO:00068 |
fraction of stomach |
A dimensionless fraction of volume defined as the stomach volume divided per unit of total body weight.
|
fstomach
|
| PBPKO:00073 |
volume of large intestine |
A volume parameter representing the total volume of the large intestine compartment.
|
vlarge intestine
|
| PBPKO:00418 |
blood flow rate to cecum |
A blood flow rate parameter specifically describing the rate to the cecum compartment.
|
qcecum
|
| PBPKO:00065 |
glomerular filtration rate |
A bodily fluid flow rate parameter (or physiological process measure) describing the flow rate of filtered fluid through the kidney compartment.
|
gfr
|
| PBPKO:00629 |
amount in richly perfused tissue |
The amount of compound in the richly perfused tissue compartment.
|
arichlyperfused
|
| PBPKO:04068 |
volume of intestinal lumen |
|
|
| PBPKO:00137 |
hydrogen donor count |
A physicochemical parameter representing the integer number of hydrogen bond donors in a molecular entity.
|
|
| PBPKO:03039 |
medium mitochondria partition coefficient |
|
|
| PBPKO:00028 |
blood flow rate to muscle |
A blood flow rate parameter specifically describing the rate to the muscle compartment.
|
qmuscle
|
| PBPKO:00029 |
fraction of blood flow to muscle |
The dimensionless fraction of cardiac output delivered to the muscle compartment.
|
fqmuscle
|
| PBPKO:00019 |
fraction of blood flow to small intestine |
The dimensionless fraction of cardiac output delivered to the small intestine compartment.
|
fqsmallintestine
|
| PBPKO:00063 |
arterial blood flow rate |
A blood flow rate parameter representing the rate of blood flow through the arterial compartment.
|
|
| PBPKO:00306 |
maximum rate of apical transporter in vitro |
A maximum rate (Vmax) of an enzyme catalysed reaction for a compound across the apical membrane of an organ, measured in vitro, when the enzyme is saturated with substrate.
|
vmax apical in vitro
|
| PBPKO:03027 |
metabolism rate constant in liver |
A biochemical parameter representing the rate of chemical biotransformation occurring specifically in the liver compartment.
|
|
| PBPKO:00518 |
restbody plasma partition coefficient |
A partition coefficient representing the ratio of compound concentration in the rest of body compartment to plasma.
|
restbody plasma pc
|
| PBPKO:00164 |
fraction unbound enterocytes |
An unbound fraction parameter specifically within enterocytes.
|
fuenterocytes
|
| PBPKO:00036 |
blood flow rate to skin |
A blood flow rate parameter specifically describing the rate to the skin compartment.
|
qskin
|
| PBPKO:00021 |
fraction of blood flow to large intestine |
The dimensionless fraction of cardiac output delivered to the large intestine compartment.
|
fqlargeinestine
|
| PBPKO:00181 |
poor perfused plasma partition coefficient |
A partition coefficient representing the ratio of compound concentration in the lumped poorly perfused compartment to plasma.
|
poor perfused plasma pc
|
| PBPKO:04059 |
skin area |
A physiological parameter representing the total surface area of the skin.
|
|
| PBPKO:00360 |
blood flow rate to frontal cortex |
A blood flow rate parameter specifically describing the rate to the frontal cortex compartment.
|
qfrontalcortex
|
| PBPKO:00307 |
Michaelis constant apical |
Michaelis constant representing the substrate concentration at half-maximal velocity (Km) for an apical transporter.
|
km apical
|
| PBPKO:04091 |
fraction of testis |
A fraction of volume of compartment defined as the testis volume divided per unit of total body weight.
|
|
| PBPKO:00564 |
blood flow rate to skin stratum corneum unexposed |
A blood flow rate to skin parameter specifically describing the rate to the unexposed stratum corneum compartment.
|
qskinscu
|
| PBPKO:00534 |
urinary rate |
A biochemical parameter representing the rate at which a compound is cleared via urine.
|
kurine
|
| PBPKO:00370 |
apparent permeability cortex to rest of brain |
Apparent permeability of a compound specifically between the cortex and the rest of the brain.
|
papp cortex brain
|
| PBPKO:00034 |
blood flow rate to gonad |
A blood flow parameter specifically describing the rate to the gonads compartment.
|
qgonad
|
| PBPKO:00166 |
gut plasma partition coefficient |
A partition coefficient representing the ratio of compound concentration in gut to plasma.
|
gut plasma pc
|
| PBPKO:04015 |
plasma flow rate to brain |
A plasma flow rate parameter specifically describing the rate to the brain compartment.
|
qbrain_p
|
| PBPKO:00340 |
middle age lifestage |
A lifestage parameter representing individuals typically from thirty to forty-five years old.
|
|
| PBPKO:03001 |
intrinsic gastric emptying rate |
The absorption rate constant parameter representing the intrinsic rate of the chemical release from stomach to lumen or the jejunum segment
|
kstoC
|
| PBPKO:00314 |
interstitial space |
A physiological parameter representing the fluid-filled space between blood vessels and cells.
|
|
| PBPKO:00262 |
half-life |
An output parameter representing the time required for the compound concentration to decrease by half (t1/2).
|
t1/2
|
| PBPKO:03038 |
medium air partition coefficient |
|
|
| PBPKO:04097 |
fraction of cortical bone |
A fraction of volume of compartment defined as the cortical bone volume divided per unit of total body weight.
|
|
| PBPKO:04007 |
plasma flow rate to liver |
A plasma flow rate parameter specifically describing the rate to the liver compartment.
|
|
| PBPKO:06029 |
total venous concentration of compound in compartment |
|
|
| PBPKO:06043 |
concentration in jejunum |
The concentration of chemical in jejunum compartment.
|
cj
|
| PBPKO:04060 |
thickness epidermis |
A skin thickness parameter representing the vertical depth of the epidermis.
|
|
| SBO:0000027 |
Michaelis constant |
|
|
| PBPKO:00122 |
venous volume |
A volume parameter representing the total volume of the venous compartment.
|
|
| PBPKO:04048 |
diameter of the ileum lumen |
|
|
| PBPKO:00101 |
volume of richly perfused |
A volume parameter representing the total volume of the richly perfused compartment.
|
vrichly perfused
|
| PBPKO:03003 |
intrinsic stomach uptake rate |
The absorption rate constant parameter representing the intrinsic absorption rate of a chemical from the stomach to the gut tissue or any intestinal segment
|
k0C
|
| PBPKO:00156 |
fraction unbound muscle |
An unbound fraction parameter specifically for the muscle compartment.
|
fumuscle
|
| PBPKO:00252 |
output parameter |
A parameter representing a result or prediction generated by the PBPK model.
|
|
| PBPKO:00085 |
volume of fat |
A volume parameter representing the total volume of fat (adipose tissue) compartment.
|
vfat
|
| PBPKO:04054 |
fraction of bile in small intestine |
A fraction of volume of compartment defined as the volume of bile in the small intestine divided per unit of total body weight.
|
|
| PBPKO:04026 |
plasma flow rate to ileum |
A plasma flow rate parameter specifically describing the rate to the ileum compartment.
|
|
| PBPKO:04020 |
plasma flow rate to restbody |
A plasma flow rate parameter specifically describing the rate to the rest of the body compartment.
|
|
| PBPKO:00109 |
volume of exposed skin |
A volume parameter representing the total volume of the exposed skin compartment.
|
vskin e
|
| PBPKO:00052 |
blood flow rate to gall bladder |
A blood flow rate parameter specifically describing the rate to the gall bladder compartment.
|
qgallbladder
|
| PBPKO:06021 |
unbound venous kidney concentration |
The unbound venous concentration of compound in the kidney compartment.
|
cvkidney_unbound
|
| PBPKO:00169 |
pancreas plasma partition coefficient |
A partition coefficient representing the ratio of compound concentration in pancreas to plasma.
|
pancreas plasma pc
|
| PBPKO:03011 |
kinetic absorption rate from ileum lumen to intestinal tissue |
A biochemical parameter representing therate constant at which a chemical moves from the ileal lumen into the intestinal tissue.
|
|
| PBPKO:04002 |
plasma flow rate to stomach |
A plasma flow rate parameter specifically describing the rate to the stomach compartment.
|
|
| PBPKO:03068 |
nominal concentration of medium |
|
|
| PBPKO:06032 |
total venous kidney concentration |
The total venous concentration of compound in the kidney compartment.
|
cvkidney
|
| PBPKO:00268 |
absolute bioavailability |
A bioavailability parameter comparing the amount reaching systemic circulation after non-IV administration to the amount available after IV administration.
|
fabs
|
| PBPKO:04036 |
plasma flow rate to skin stratum corneum unexposed |
A plasma flow rate parameter specifically describing the rate to the unexposed stratum corneum compartment.
|
|
| PBPKO:06035 |
total venous lung concentration |
The total venous concentration of compound in the lung compartment.
|
cvlung
|
| PBPKO:04070 |
volume of large intestinal lumen |
|
|
| PBPKO:00233 |
biliary clearance rate |
A clearance rate specifically quantifying elimination via bile.
|
|
| PBPKO:00529 |
blood flow rate to filtrate |
A blood flow rate parameter specifically describing the rate to the filtrate compartment (representing glomerular filtration).
|
qfiltrate
|
| PBPKO:00283 |
percentile 97.5 cplasma |
A plasma concentration parameter representing the 97.5th percentile of the plasma concentration distribution in a population simulation.
|
|
| PBPKO:06025 |
unbound venous bone marrow concentration |
The unbound venous concentration of compound in the bone marrow compartment.
|
cvbm_unbound
|
| PBPKO:00095 |
volume of spleen |
A volume parameter representing the total volume of the spleen compartment.
|
vspleen
|
| PBPKO:00372 |
fetoplacental volume |
A volume parameter representing the total volume of the placental compartment for fetus.
|
|
| PBPKO:00300 |
concentration in teeth |
A biological matrix concentration specifically representing the total concentration of compound in the teeth compartment.
|
cteeth
|
| PBPKO:00505 |
amount in bone marrow |
The amount of compound in the bone marrow compartment.
|
abm
|
| PBPKO:00069 |
volume of intestine |
A volume parameter representing the total volume of the intestine compartment.
|
vintestine
|
| PBPKO:00158 |
fraction unbound fat |
An unbound fraction parameter specifically for the fat (adipose) compartment.
|
fufat
|
| PBPKO:00092 |
fraction of bone |
A dimensionless fraction of volume defined as the bone volume divided per unit of total body weight.
|
fbone
|
| PBPKO:00414 |
blood flow rate to duodenum |
A blood flow rate parameter specifically describing the rate to the duodenum compartment.
|
qduodenum
|
| PBPKO:00035 |
fraction of blood flow to gonad |
The dimensionless fraction of cardiac output delivered to the gonad compartment.
|
fqgonad
|
| PBPKO:00389 |
maximum rate in fetus |
A maximum rate (Vmax) of an enzyme catalysed reaction for a compound in fetus when the enzyme is saturated with substrate.
|
vmax fetus
|
| PBPKO:03030 |
red blood cells partition coefficient |
A biochemical parameter representing the ratio of chemical concentration in red blood cells to that in plasma at equilibrium.
|
|
| PBPKO:06049 |
concentration in spleen |
The concentration of chemical in spleen compartment.
|
cspleen
|
| PBPKO:00030 |
blood flow rate to heart |
A blood flow rate parameter specifically describing the rate to the heart compartment.
|
qheart
|
| PBPKO:00511 |
fraction of blood flow to filtrate |
The dimensionless fraction of cardiac output delivered to the filtrate compartment.
|
fqfiltrate
|
| PBPKO:03023 |
intrinsic reabsorption rate constant |
A biochemical parameter representing the rate constant at which a substance is reabsorbed from a secretory compartment.
|
|
| PBPKO:04028 |
plasma flow rate to cecum |
A plasma flow rate parameter specifically describing the rate to the cecum compartment.
|
qcecum_p
|
| PBPKO:00089 |
volume of skin |
A volume parameter representing the total volume of the skin compartment.
|
vskin
|
| PBPKO:00547 |
concentration in mammary gland |
The total concentration of compound in the mammary gland compartment.
|
cmam
|
| PBPKO:03042 |
medium microsomes partition coefficient |
|
|
| PBPKO:00541 |
concentration in kidney |
The total concentration of compound in the kidney compartment.
|
ckidney
|
| PBPKO:00187 |
blood:plasma ratio |
A biochemical parameter representing the ratio of compound concentration in whole blood to that in plasma.
|
bp
|
| PBPKO:00543 |
concentration in lung |
The total concentration of compound in the lung compartment.
|
clung
|
| PBPKO:00113 |
volume of unexposed stratum corneum |
A volume parameter representing the total volume of the unexposed stratum corneum compartment.
|
vskin sc u
|
| PBPKO:00121 |
arterial volume |
A volume parameter representing the total volume of the arterial compartment.
|
|
| PBPKO:00116 |
fraction of gall bladder |
A dimensionless fraction of volume defined as the gall bladder volume divided per unit of total body weight.
|
fgall bladder
|
| PBPKO:06047 |
concentration in lumen |
The concentration of chemical in lumen of intestine.
|
clumen
|
| PBPKO:00138 |
rotatable bond count |
A physicochemical parameter representing the integer count of rotatable bonds in a molecular entity.
|
|
| PBPKO:00108 |
volume of blood |
A volume parameter representing the total volume of blood compartment.
|
vblood
|
| PBPKO:06058 |
concentration in microsomes |
|
|
| PBPKO:00248 |
subcutaneous exposure |
A route of exposure involving administration under the skin.
|
|
| PBPKO:00153 |
fraction unbound pancreas |
An unbound fraction parameter specifically for the pancreas compartment.
|
fupancreas
|
| PBPKO:00578 |
liverfetus blood partition coefficient |
A partition coefficient representing the ratio of compound concentration in the fetal liver to blood.
|
liverfetus blood pc
|
| PBPKO:00430 |
mean precipitation time |
A biochemical parameter representing the average time for a compound to precipitate under specific conditions (e.g., in the GI tract).
|
|
| PBPKO:03034 |
partition coeffcient of stratum corneum to skin surface depot |
A partition coefficient representing the ratio of chemical concentration in the outer skin to the surface application site at equilibrium.
|
|
| PBPKO:00179 |
lung plasma partition coefficient |
A partition coefficient representing the ratio of compound concentration in lung to plasma.
|
lung plasma pc
|
| PBPKO:00643 |
thickness stratum corneum |
A skin thickness parameter representing the thickness of stratum corneum.
|
height_sc
Thickness_SC
|
| PBPKO:06048 |
concentration in bile |
The concentration of chemical in bile.
|
cbile
|
| PBPKO:00009 |
height |
A physiological parameter describing the distance from the bottom to the top of someone standing upright.
|
ht
|
| PBPKO:00337 |
teenager lifestage |
A lifestage parameter representing individuals typically between eleven and fifteen years old.
|
|
| PBPKO:00135 |
physiological charge |
A physicochemical parameter representing the electrical charge of a molecule at physiological pH.
|
|
| PBPKO:00155 |
fraction unbound kidney |
An unbound fraction parameter specifically for the kidney compartment.
|
fukidney
|
| PBPKO:00016 |
blood flow rate to intestine |
A blood flow parameter specifically describing the rate to the intestine compartment.
|
qintestine
|
| PBPKO:00424 |
volume of duodenum |
A volume parameter representing the total volume of the duodenum compartment.
|
vduodenum
|
| PBPKO:00033 |
fraction of blood flow to fat |
The dimensionless fraction of cardiac output delivered to the fat compartment.
|
fqfat
|
| PBPKO:04037 |
plasma flow rate to skin stratum corneum exposed |
A plasma flow rate parameter specifically describing the rate to the exposed stratum corneum compartment.
|
|
| PBPKO:00540 |
concentration in brain |
The total concentration of compound in the brain compartment.
|
cbrain
|
| PBPKO:00610 |
fraction of volume of compartment |
A physiological parameter representing the dimensionless fraction computed by dividing the volume of the compartment by the total body weight.
|
|
| PBPKO:00066 |
volume of compartment |
A physiological parameter representing the volume of a specific organ or tissue.
|
Vorgan
|
| PBPKO:04040 |
volumen of lumen |
|
|
| PBPKO:06031 |
total venous gut concentration |
The total venous concentration of compound in the gut compartment.
|
cvgut
|
| PBPKO:04009 |
plasma flow rate to muscle |
A plasma flow rate parameter specifically describing the rate to the muscle compartment.
|
|
| PBPKO:00103 |
volume of plasma |
A volume parameter representing the total volume of plasma compartment.
|
vplasma
|
| PBPKO:00530 |
blood flow rate to bone marrow |
A blood flow parameter specifically describing the rate to the bone marrow compartment.
|
qbm
|
| PBPKO:04061 |
volume of exposed viable epidermis |
A volume of compartment representing the living skin layer under the application site.
|
|
| PBPKO:00076 |
fraction of pancreas |
A dimensionless fraction of volume defined as the pancreas volume divided per unit of total body weight.
|
fpancreas
|
| PBPKO:00024 |
blood flow rate to liver |
A blood flow rate parameter specifically describing the rate to the liver compartment.
|
qliver
|
| PBPKO:03059 |
fraction of albumin in the FBS |
|
|
| PBPKO:00590 |
stomach blood partition coefficient |
A partition coefficient representing the ratio of compound concentration in the stomach to blood.
|
stomach blood pc
|
| PBPKO:04022 |
plasma flow rate to portal vein |
A plasma flow rate parameter specifically describing the rate to the portal vein compartment.
|
|
| PBPKO:04006 |
plasma flow rate to pancreas |
A plasma flow rate parameter specifically describing the rate to the pancreas compartment.
|
|
| PBPKO:00568 |
air blood partition coefficient |
A partition coefficient representing the ratio of compound concentration in air to blood.
|
air blood pc
|
| PBPKO:00580 |
mammary gland blood partition coefficient |
A partition coefficient representing the ratio of compound concentration in the mammary gland to blood.
|
mam blood pc
|
| PBPKO:00082 |
fraction of muscle |
A dimensionless fraction of volume defined as the muscle volume divided per unit of total body weight.
|
fmuscle
|
| PBPKO:00506 |
amount in skin |
The amount of compound in the skin compartment.
|
askin
|
| PBPKO:04089 |
fraction of stomach lumen |
A fraction of volume of compartment defined as the stomach lumen volume divided per unit of total body weight.
|
|
| PBPKO:04083 |
fraction of adrenals |
|
|
| PBPKO:00521 |
age in PBPK model |
A physiological parameter representing the period of lifespan (typically in years) for which the model is simulated.
|
|
| PBPKO:00136 |
hydrogen acceptor count |
A physicochemical parameter representing the integer number of hydrogen bond acceptors in a molecular entity.
|
A
|
| PBPKO:04081 |
volume of alveolar compartment |
|
|
| PBPKO:00392 |
brainfetus plasma partition coefficient |
A partition coefficient representing the ratio of compound concentration in the fetal brain to plasma.
|
brainfetus plasma pc
|
| PBPKO:06060 |
concentration in polymer |
|
|
| PBPKO:03014 |
apparent Caco-2 permeability |
A biochemical parameter representing the observed rate constant of compound transport across a Caco-2 cell monolayer.
|
|
| PBPKO:00131 |
logarithmic solubility |
A physicochemical parameter representing the 10-based logarithm of a compound's solubility (typically in mol/L).
|
log S
|
| PBPKO:00211 |
maximum rate in intestine |
A maximum rate (Vmax) of an enzyme catalysed reaction for a compound in the intestine when the enzyme is saturated with substrate.
|
vmax intestine
|
| PBPKO:00044 |
blood flow rate to lung |
A blood flow rate parameter specifically describing the rate to the lung compartment.
|
qlung
|
| PBPKO:03028 |
metabolism rate constant in intestinal tissue |
A biochemical parameter representing the rate of chemical biotransformation occurring specifically in the intestinal wall.
|
|
| PBPKO:04043 |
enterocyte volume |
|
|
| PBPKO:00086 |
fraction of fat |
A dimensionless fraction of volume defined as the fat volume divided per unit of total body weight.
|
ffat
|
| PBPKO:00171 |
kidney plasma partition coefficient |
A partition coefficient representing the ratio of compound concentration in kidney to plasma.
|
kidney plasma pc
|
| PBPKO:03009 |
kinetic emptying rate from ileum lumen to large intestine lumen |
A biochemical parameter representing the rate constant of passage of contents from the ileum to the colon.
|
|
| PBPKO:00247 |
intrathecal exposure |
A route of exposure involving administration into the spinal canal.
|
|
| PBPKO:00018 |
blood flow rate to small intestine |
A blood flow rate parameter specifically describing the rate to the small intestine compartment.
|
qsmall intestine
|
| PBPKO:03060 |
culture area |
|
|
| PBPKO:00102 |
fraction of richly perfused |
A dimensionless fraction of volume defined as the richly perfused compartment volume divided per unit of total body weight.
|
frichly perfused
|
| PBPKO:00339 |
adult lifestage |
A lifestage parameter representing individuals typically from eighteen to thirty years old.
|
|
| PBPKO:00374 |
volume of placenta |
A volume parameter representing the total volume of the placental compartment.
|
vplacenta
|
| PBPKO:00423 |
fraction of cecum |
A dimensionless fraction of volume defined as the cecum volume divided per unit of total body weight.
|
fcecum
|
| PBPKO:03070 |
fraction of FBS iin the medium |
|
|
| PBPKO:04063 |
area of exposed skin |
A physiological parameter representing the specific skin area where exposure occurs.
|
|
| PBPKO:00341 |
old age lifestage |
A lifestage parameter representing individuals typically from forty-five to sixty years old (or older, definitions vary).
|
|
| PBPKO:00410 |
fraction of blood flow to jejunum |
The dimensionless fraction of cardiac output delivered to the jejunum compartment.
|
fqjejunum
|
| PBPKO:00413 |
fraction of blood flow to cecum |
The dimensionless fraction of cardiac output delivered to the cecum compartment.
|
fqcecum
|
| PBPKO:03044 |
medium albumin partition coefficient |
|
|
| PBPKO:06036 |
total venous fat concentration |
The total venous concentration of compound in the fat compartment.
|
cvfat
|
| PBPKO:00526 |
volume of mass balance |
A volume parameter representing the check for total mass balance of all compartments (sum of organ volumes should equal body volume/weight equivalent, depending on units).
|
vmass bal
|
| PBPKO:03016 |
Hill dissociation constant |
A biochemical parameter representing the ligand concentration at which half of the binding sites are occupied.
|
|
| PBPKO:00622 |
fraction unbound blood |
An unbound fraction parameter specifically for the blood compartment.
|
fublood
|
| PBPKO:00297 |
biological matrix concentration |
An output parameter representing the total concentration of a compound in a specified biological matrix.
|
|
| PBPKO:00431 |
diffusion coefficient |
A physicochemical parameter representing the amount of substance diffusing across a unit area per unit time under a unit concentration gradient.
|
D
|
| PBPKO:03035 |
partition coeffcient of follicle to skin surface depot |
A partition coefficient representing the ratio of chemical concentration in the follicles to the surface application site at equilibrium.
|
|
| PBPKO:00264 |
relative bioavailability |
A bioavailability parameter comparing the rate and extent of absorption of a test compound to a reference compound.
|
frel
|
| PBPKO:04074 |
volume of uterus |
|
|
| PBPKO:00041 |
fraction of blood flow to brain |
The dimensionless fraction of cardiac output delivered to the brain compartment.
|
fqbrain
|
| PBPKO:03024 |
reabsorption rate constant |
A biochemical parameter representing the allometrically scaled rate constant or the re-uptake of a chemical back into the blood (dependent on species).
|
|
| PBPKO:00244 |
intravenous infusion exposure |
A route of exposure involving continuous administration directly into a vein over time.
|
IVI
|
| PBPKO:00145 |
specific intestinal permeability |
A biochemical parameter representing the surface area-normalized transcellular permeability of the intestinal wall for a compound.
|
|
| PBPKO:00637 |
amount in viable epidermis of unexposed skin |
The amount of chemical in viable epidermis of unexposed skin
|
askin_u
|
| PBPKO:06037 |
total venous bone marrow concentration |
The total venous concentration of compound in the bone marrow compartment.
|
cvbm
|
| PBPKO:00289 |
reference dose |
An output parameter (or exposure limit) estimating the daily oral or dermal exposure likely to be without appreciable risk over a lifetime (RfD).
|
RfD
|
| PBPKO:06019 |
unbound venous gut concentration |
The unbound venous concentration of compound in the gut compartment.
|
cvgut_unbound
|
| PBPKO:00127 |
molecular weight |
A physicochemical parameter representing the sum of the weights of all atoms in a molecule.
|
MW
|
| PBPKO:00184 |
skin diffusion coefficient |
A diffusion coefficient representing the diffusion of a compound across the skin.
|
kp sc
|
| PBPKO:03056 |
cell fraction of lysosomes |
|
|
| PBPKO:00432 |
particle density |
A biochemical/physical parameter representing the mass per unit volume of particles (e.g., of the administered compound).
|
ps
|
| PBPKO:00152 |
fraction unbound intestine |
An unbound fraction parameter specifically for the intestine compartment.
|
fuintestine
|
| PBPKO:03065 |
fraction of serum in total media |
|
|
| PBPKO:00182 |
skin stratum corneum partition coefficient |
A partition coefficient representing the ratio of compound concentration in the stratum corneum to the rest of the skin.
|
skin sc pc
|
| PBPKO:04039 |
blood flow rate to red blood cells |
A blood flow rate to compartment representing the volume of blood per unit time moving through the red blood cell mass.
|
|
| PBPKO:04014 |
plasma flow rate to bone |
A plasma flow rate parameter specifically describing the rate to the bone compartment.
|
qbone_p
|
| PBPKO:03073 |
fraction unbound in the FBS |
|
|
| PBPKO:00290 |
acceptable daily intake |
An output parameter (or exposure limit) estimating the amount of a substance in food/water that can be consumed daily without appreciable health risk (ADI).
|
adi
|
| PBPKO:00286 |
estimated daily intake |
An output parameter estimating the amount of a compound consumed daily (EDI).
|
edi
|
| PBPKO:00081 |
volume of muscle |
A volume parameter representing the total volume of muscle compartment.
|
vmuscle
|
| PBPKO:00375 |
volume of amniotic fluid |
A volume parameter representing the total volume of the amniotic fluid compartment.
|
vaf
|
| PBPKO:00352 |
spinal cerebrospinal fluid flow rate |
A bodily fluid flow rate parameter representing the flow rate of cerebrospinal fluid (CSF) compartment in the spinal region.
|
spinal csf flow
|
| PBPKO:00091 |
volume of bone |
A volume parameter representing the total volume of bone compartment.
|
vbone
|
| PBPKO:00006 |
physiological parameter |
A parameter that provides the structural framework for a PBPK model and relates to the organism's physiology (e.g., body weight, organ volume, blood flow).
|
|
| PBPKO:00615 |
amount of compound in compartment |
An output parameter representing the amount of chemical specifically in the compartment
|
|
| PBPKO:00411 |
fraction of blood flow to ileum |
The dimensionless fraction of cardiac output delivered to the ileum compartment.
|
fqileum
|
| PBPKO:03007 |
intrinsic biliary clearance rate |
A biochemical parameter representing the allometrically scaled biliary excretion rate constant of the liver to clear a chemical into the bile (dependent on species).
|
|
| PBPKO:05001 |
molar volume |
A physicochemical parameter representing the volume of one mole of a molecule.
|
MV
|
| PBPKO:04032 |
plasma flow rate to mammary gland |
A plasma flow rate parameter specifically describing the rate to the mammary gland compartment.
|
|
| PBPKO:03066 |
FBS pH |
|
|
| PBPKO:03020 |
intrinsic enterohepatic recirculation rate constant |
A biochemical parameter representing the rate constant for the cycling of a chemical from the bile back to the liver via the intestine.
|
|
| PBPKO:00338 |
adolescent lifestage |
A lifestage parameter representing the transitional stage between teenager and adulthood (approx. 15-18 years).
|
|
| PBPKO:06040 |
total venous rest body concentration |
The total venous concentration of compound in the rest of the body compartment.
|
cvrestbody
|
| PBPKO:04008 |
plasma flow rate to kidney |
A plasma flow rate parameter specifically describing the rate to the kidney compartment.
|
|
| PBPKO:00053 |
fraction of blood flow to gall bladder |
The dimensionless fraction of cardiac output delivered to the gall bladder compartment.
|
fqgallbladder
|
| PBPKO:05002 |
Henry's law constant |
A physicochemical parameter describing the volatily of a compound
|
Henry
|
| PBPKO:00498 |
amount in kidney |
The amount of compound in the kidney compartment.
|
akidney
|
| PBPKO:00110 |
fraction of surface area exposed |
A surface area parameter representing the fraction of skin surface area actually exposed.
|
fsa exposed
|
| PBPKO:04092 |
fraction of uterus |
A fraction of volume of compartment defined as the uterus volume divided per unit of total body weight.
|
|
| PBPKO:03075 |
absorption rate constant |
A biochemical parameter representing the rate constant at which a compound is absorbed into systemic circulation or a target compartment from the site of administration
|
ka
|
| PBPKO:03026 |
half-saturation concentration of chemical for binding by sites in red cells |
A biochemical parameter representing the concentration at which half of the red blood cell binding sites are saturated.
|
|
| PBPKO:06045 |
concentration in large intestine |
The concentration of chemical in large intestine compartment.
|
cli
|
| PBPKO:00250 |
transdermal exposure |
A route of exposure involving absorption through the skin, typically from a patch.
|
|
| PBPKO:06034 |
total venous filtrate concentration |
The total venous concentration of compound in the filtrate compartment.
|
cvfiltrate
|
| PBPKO:00236 |
fecal elimination rate constant |
A biochemical parameter representing the rate constant for elimination via fecal excretion.
|
|
| PBPKO:00075 |
volume of pancreas |
A volume parameter representing the total volume of the pancreas compartment.
|
vpancreas
|
| PBPKO:00426 |
volume of ileum |
A volume parameter representing the total volume of the ileum compartment.
|
vileum
|
| PBPKO:00173 |
heart plasma partition coefficient |
A partition coefficient representing the ratio of compound concentration in heart to plasma.
|
heart plasma pc
|
| PBPKO:04080 |
volume of trabecular bone |
|
|
| PBPKO:00151 |
fraction unbound stomach |
An unbound fraction parameter specifically for the stomach compartment.
|
fustomach
|
| PBPKO:06002 |
unbound venous concentration of compound in compartment |
|
|
| PBPKO:00267 |
bioequivalence |
An output parameter indicating comparable bioavailability between test and reference formulations under similar conditions.
|
be
|
| PBPKO:00090 |
fraction of skin |
A dimensionless fraction of volume defined as the skin volume divided per unit of total body weight.
|
fskin
|
| PBPKO:03072 |
fraction unbound in the medium |
|
|
| PBPKO:03067 |
initial number of cells |
|
|
| PBPKO:00100 |
fraction of poorly perfused |
A dimensionless fraction of volume defined as the poorly perfused compartment volume divided per unit of total body weight.
|
fpoorly perfused
|
| PBPKO:00031 |
fraction of blood flow to heart |
The dimensionless fraction of cardiac output delivered to the heart compartment.
|
fqheart
|
| PBPKO:00154 |
fraction unbound liver |
An unbound fraction parameter specifically for the liver compartment.
|
fuliver
|
| PBPKO:06016 |
amount in portal vein |
The amount of chemical in portal vein.
|
apv
|
| PBPKO:00302 |
concentration in urine |
A biological matrix concentration specifically representing the total concentration of compound in the urine compartment.
|
curine
|
| PBPKO:04069 |
volume of small intestinal lumen |
|
|
| PBPKO:00582 |
muscle blood partition coefficient |
A partition coefficient representing the ratio of compound concentration in muscle to blood.
|
muscle blood pc
|
| PBPKO:00589 |
spleen blood partition coefficient |
A partition coefficient representing the ratio of compound concentration in the spleen to blood.
|
spleen blood pc
|
| PBPKO:00612 |
apparent permeability |
A biochemical parameter representing the apparent permeability of a compound specifically between the compartments.
|
|
| PBPKO:00298 |
concentration in hair |
The total concentration of compound in the hair compartment.
|
chair
|
| PBPKO:00241 |
dermal exposure |
A route of exposure via the skin.
|
|
| PBPKO:00539 |
concentration in liver |
The total concentration of compound in the liver compartment.
|
cliver
|
| PBPKO:04049 |
diameter of the large intestine lumen |
|
|
| PBPKO:00496 |
amount in gut |
The amount of compound in the gut compartment.
|
agut
|
| PBPKO:00032 |
blood flow rate to fat |
A blood flow rate parameter specifically describing the rate to the fat (adipose tissue) compartment.
|
qfat
|
| PBPKO:06013 |
amount in spleen |
The amount of chemical in spleen compartment
|
aspleen
|
| PBPKO:00384 |
blood flow rate to kidneyfetus |
A blood flow rate parameter specifically describing the rate to the fetal kidney compartment.
|
qkidneyfetus
|
| PBPKO:00513 |
fraction of blood flow to gut |
The dimensionless fraction of cardiac output delivered to the gut compartment.
|
fqgut
|
| PBPKO:04067 |
volume of thyroid |
|
|
| PBPKO:00114 |
fraction alveolar volume |
A dimensionless fraction of volume defined as the alveolar volume divided per unit of total body weight.
|
falv
|
| PBPKO:00008 |
bodyweight |
A physiological parameter representing the mass or quantity of heaviness of an individual.
|
bw
|
| PBPKO:04090 |
fraction of gut intestinal tract |
A fraction of volume of compartment defined as the gut intestinal tract volume divided per unit of total body weight.
|
|
| PBPKO:04051 |
surface area of the ileum lumen |
|
|
| PBPKO:00013 |
cardiac output rate |
A blood flow rate parameter representing the volume of blood pumped by the heart compartment per unit of time.
|
CO
|
| PBPKO:00170 |
liver plasma partition coefficient |
A partition coefficient representing the ratio of compound concentration in liver to plasma.
|
liver plasma pc
|
| PBPKO:00117 |
volume of portal vein |
A volume parameter representing the total volume of the portal vein compartment.
|
vportal vein
|
| PBPKO:00512 |
fraction of blood flow to bone marrow |
The dimensionless fraction of cardiac output delivered to the bone marrow compartment.
|
fqbm
|
| PBPKO:00649 |
miscellaneous parameter |
A parameter being used in the model but does not belong to specific parameter subclass
|
|
| PBPKO:00439 |
daily milk intake |
A physiological parameter representing the daily volume of milk ingested (e.g., by an infant).
|
|
| PBPKO:00586 |
restbodyfetus blood partition coefficient |
A partition coefficient representing the ratio of compound concentration in the fetal rest of body compartment to blood.
|
restbodyfetus blood pc
|
| PBPKO:03032 |
partition coeffcient of stratum corneum to viable epidermis |
A partition coefficient representing the ratio of chemical concentration in the stratum corneum to the viable epidermis at equilibrium.
|
|
| PBPKO:00515 |
brain plasma partition coefficient |
A partition coefficient representing the ratio of compound concentration in the brain to plasma.
|
brain plasma pc
|
| PBPKO:00333 |
fetus lifestage |
A lifestage parameter representing the unborn offspring from the postembryonic stage until birth.
|
|
| PBPKO:00119 |
volume of lymph |
A volume parameter representing the total volume of lymph compartment.
|
vlymph
|
| PBPKO:00084 |
fraction of heart |
A dimensionless fraction of volume defined as the heart volume divided per unit of total body weight.
|
fheart
|
| PBPKO:06023 |
unbound venous lung concentration |
The unbound venous concentration of compound in the lung compartment.
|
cvlung_unbound
|
| PBPKO:00377 |
volume of brain fetus |
A volume parameter representing the total volume of the fetal brain compartment.
|
vbrainfetus
|
| PBPKO:00628 |
fraction of venous plasma volume |
A dimensionless fraction of volume defined as the venous plasma volume divided per unit of total body weight.
|
fvenousplasma
|
| PBPKO:00070 |
fraction of intestine |
A dimensionless fraction of volume defined as the intestine volume divided per unit of total body weight.
|
fintestine
|
| PBPKO:00383 |
blood flow rate to liverfetus |
A blood flow rate parameter specifically describing the rate to the fetal liver compartment.
|
qliverfetus
|
| PBPKO:00638 |
amount in viable epidermis of exposed skin |
The amount of chemical in viable epidermis of exposed skin
|
askin_e
|
| PBPKO:00245 |
intramuscular exposure |
A route of exposure involving injection into a muscle.
|
|
| PBPKO:00429 |
bile salt effect solubilization ratio |
A biochemical parameter representing the ratio of molecules solubilized due to bile salt presence.
|
|
| PBPKO:00265 |
mean absorption time |
An output parameter representing the average time for a compound to be absorbed into systemic circulation (MAT).
|
MAT
|
| PBPKO:00175 |
gonad plasma partition coefficient |
A partition coefficient representing the ratio of compound concentration in gonads to plasma.
|
gonads plasma pc
|
| PBPKO:00111 |
volume of unexposed skin |
A volume parameter representing the total volume of the unexposed skin compartment.
|
vskin u
|
| PBPKO:00537 |
octanol air partition coefficient |
A partition coefficient (Koa) representing the ratio of compound concentration in octanol to air at equilibrium.
|
koa
|
| PBPKO:00142 |
absorption rate constant intestine |
An absorption rate constant parameter representing the movement of a compound from the intestine to systemic circulation or another compartment.
|
Kac intestine
|
| PBPKO:06061 |
concentration in air |
|
|
| PBPKO:04099 |
fraction of the skin surface depot |
A fraction of volume of compartment defined as the skin surface depot volume divided per unit of total body weight.
|
|
| PBPKO:06008 |
amount in large intestine |
The amount of chemical in large intestine compartment.
|
ali
|
| PBPKO:00356 |
volume of frontal cortex |
A volume parameter representing the total volume of the frontal cortex compartment.
|
vfrontal cortex
|
| PBPKO:00049 |
fraction of blood flow to richly perfused |
The dimensionless fraction of cardiac output delivered to the richly perfused compartment.
|
fqrichlyperfused
|
| PBPKO:04012 |
plasma flow rate to gonad |
A plasma flow rate parameter specifically describing the rate to the gonad compartment.
|
|
| PBPKO:06030 |
total venous liver concentration |
The total venous concentration of compound in the liver compartment.
|
cvliver
|
| PBPKO:00010 |
surface area |
A physiological parameter representing the total area that the surface of an object occupies.
|
BSA/SA
|
| PBPKO:00165 |
partition coefficient |
A biochemical parameter representing the ratio of the concentration of a compound in a particular tissue to its concentration in plasma/blood at equilibrium.
|
Kp
|
| PBPKO:00126 |
physicochemical parameter |
A parameter relating to the physical and chemical properties of a compound (e.g., MW, lipophilicity, solubility, pKa).
|
|
| PBPKO:04098 |
fraction of trabecular bone |
A fraction of volume of compartment defined as the trabecular bone volume divided per unit of total body weight.
|
|
| PBPKO:00277 |
steady state area under curve |
An area under curve parameter calculated over a dosing interval at steady state (AUCss).
|
aucss
|
| PBPKO:00256 |
area under curve |
An output parameter representing the integral of the concentration-time curve (AUC), indicating total exposure.
|
AUC
|
| PBPKO:00079 |
volume of kidney |
A volume parameter representing the total volume of the kidney compartment.
|
vkidney
|
| PBPKO:00416 |
blood flow rate to ileum |
A blood flow rate parameter specifically describing the rate to the ileum compartment.
|
qileum
|
| PBPKO:00525 |
volume of mammary gland |
A volume parameter representing the total volume of the mammary gland compartment.
|
vmam
|
| PBPKO:00562 |
blood flow rate to unexposed skin |
A blood flow rate to skin parameter specifically describing the rate to the unexposed portion of the skin compartment.
|
qskinu
|
| PBPKO:00576 |
kidneyfetus blood partition coefficient |
A partition coefficient representing the ratio of compound concentration in the fetal kidney to blood.
|
kidneyfetus blood pc
|
| PBPKO:00373 |
volume of fetus |
A volume parameter representing the total volume of the fetus.
|
vfetus
|
| PBPKO:06055 |
concentration in cell |
|
|
| PBPKO:00257 |
area under curve 0 to t |
An area under curve parameter calculated from time zero to a specific time point t (AUC0-t).
|
auc 0 to t
|
| PBPKO:00570 |
brainfetus blood partition coefficient |
A partition coefficient representing the ratio of compound concentration in the fetal brain to blood.
|
brainfetus blood pc
|
| PBPKO:00133 |
acid dissociation constant |
A physicochemical parameter representing the negative base-10 logarithm (pKa) of the acid dissociation constant (Ka).
|
pka
|
| PBPKO:03061 |
top well diameter |
|
|
| PBPKO:00234 |
hepatic clearance rate |
A clearance rate specifically quantifying elimination via the liver (metabolism and/or biliary excretion).
|
|
| PBPKO:00022 |
blood flow rate to pancreas |
A blood flow rate parameter specifically describing the rate to the pancreas compartment.
|
qpancreas
|
| PBPKO:06051 |
amount in skin surface depot |
An amount of compound in compartment representing the mass of chemical on the skin surface.
|
|
| PBPKO:04084 |
fraction of breast |
A fraction of volume of compartment defined as the breast volume divided per unit of total body weight.
|
|
| PBPKO:00305 |
Michaelis constant baso |
Michaelis constant representing the substrate concentration at half-maximal velocity (Km) for a basolateral transporter.
|
km baso
|
| PBPKO:00141 |
absorption rate constant gut |
An absorption rate constant parameter representing the rate constant for the movement of a compound from the gut to systemic circulation or another compartment.
|
Kac gut
|
| PBPKO:04073 |
volume of testis |
|
|
| PBPKO:00040 |
blood flow rate to brain |
A blood flow rate parameter specifically describing the rate to the brain compartment.
|
qbrain
|
| PBPKO:03002 |
intrinsic absorption rate |
The absorption rate constant parameter representing the intrinsic absorption rate from the gut or any intestinal segment to the liver or the portal vein
|
kabsC
|
| PBPKO:00442 |
milk plasma partition coefficient |
A partition coefficient representing the ratio of compound concentration in milk to plasma.
|
milk plasma pc
|
| PBPKO:00587 |
rich perfused blood partition coefficient |
A partition coefficient representing the ratio of compound concentration in the richly perfused compartment to blood.
|
rich perfused blood pc
|
| PBPKO:00259 |
area under curve 0 to infinity |
An area under curve parameter extrapolated from time zero to infinity (AUC0-inf), representing total exposure after a single dose.
|
auc 0 infinity
|
| PBPKO:06052 |
maximum amount |
The maximum amount of chemical in a compartment
|
amax
|
| PBPKO:04088 |
fraction of large intestinal lumen |
A fraction of volume of compartment defined as the large intestinal lumen volume divided per unit of total body weight.
|
|
| PBPKO:00369 |
apparent permeability hippocampus to rest of brain |
Apparent permeability of a compound specifically between the hippocampus and the rest of the brain.
|
papp hippocampus brain
|
| PBPKO:06005 |
amount in small intestine |
The amount of chemical in small intestine compartment
|
asi
|
| PBPKO:04094 |
fraction of hair |
A fraction of volume of compartment defined as the hair volume divided per unit of total body weight.
|
|
| PBPKO:00563 |
blood flow rate to exposed skin |
A blood flow rate to skin parameter specifically describing the rate to the exposed portion of the skin compartment.
|
qskine
|
| PBPKO:00118 |
fraction of portal vein |
A dimensionless fraction of volume defined as the portal vein volume divided per unit of total body weight.
|
fportal vein
|
| PBPKO:04025 |
plasma flow rate to jejunum |
A plasma flow rate parameter specifically describing the rate to the jejunum compartment.
|
|
| PBPKO:04011 |
plasma flow rate to fat |
A plasma flow rate parameter specifically describing the rate to the fat compartment.
|
qfat_p
|
| PBPKO:00147 |
volume of distribution |
A biochemical parameter representing the apparent volume into which a compound distributes in the body relative to its plasma concentration.
|
Vd
|
| PBPKO:06022 |
unbound venous filtrate concentration |
The unbound venous concentration of compound in the filtrate compartment.
|
cvfiltrate_unbound
|
| PBPKO:04053 |
uptake fraction to blood |
|
|
| PBPKO:03069 |
volume of medium |
|
|
| PBPKO:04086 |
fraction of intestinal lumen |
A fraction of volume of compartment defined as the intestinal lumen volume divided per unit of total body weight.
|
|
| PBPKO:06027 |
unbound venous mammary gland concentration |
The unbound venous concentration of compound in the mammary gland compartment.
|
cvmam_unbound
|
| PBPKO:03046 |
acidic phospholipid association constant |
|
|
| PBPKO:04030 |
plasma flow rate to bone marrow |
A plasma flow parameter specifically describing the rate to the bone marrow compartment.
|
qbm_p
|
| PBPKO:00177 |
bone plasma partition coefficient |
A partition coefficient representing the ratio of compound concentration in bone to plasma.
|
bone plasma pc,
k_bone_plasma
|
| PBPKO:00393 |
kidneyfetus plasma partition coefficient |
A partition coefficient representing the ratio of compound concentration in the fetal kidney to plasma.
|
kidneyfetus plasma pc
|
| PBPKO:00428 |
volume of cecum |
A volume parameter representing the total volume of the cecum compartment.
|
vcecum
|
| PBPKO:04058 |
volume fraction of red blood cells |
|
|
| PBPKO:00051 |
fraction of blood flow to restbody |
The dimensionless fraction of cardiac output delivered to the rest of the body compartment.
|
fqrestbody
|
| PBPKO:00420 |
fraction of jejunum |
A dimensionless fraction of volume defined as the jejunum volume divided per unit of total body weight.
|
fjejunum
|
| PBPKO:00584 |
poor perfused blood partition coefficient |
A partition coefficient representing the ratio of compound concentration in the poorly perfused compartment to blood.
|
poor perfused blood pc
|
| PBPKO:00632 |
amount in venous blood |
The amount of compound in the venous blood compartment.
|
avenousblood
|
| PBPKO:00523 |
volume of bone marrow |
A volume parameter representing the total volume of the bone marrow compartment.
|
vbm
|
| PBPKO:00098 |
fraction of lung |
A dimensionless fraction of volume defined as the lung volume divided per unit of total body weight.
|
flung
|
| PBPKO:00642 |
dermal absorption rate exposed skin |
An absorption rate constant parameter representing dermal absorption rate flux through exposed skin
|
fs_e
|
| PBPKO:00229 |
clearance rate |
A biochemical parameter representing the volume of biological fluid cleared of a compound per unit time.
|
cl
|
| PBPKO:03071 |
ionized fraction in the medium |
|
|
| PBPKO:00544 |
concentration in fat |
The total concentration of compound in the fat compartment.
|
cfat
|
| PBPKO:00212 |
Michaelis constant intestine |
Michaelis constant representing the substrate concentration at which the reaction rate in the intestine is half of Vmax (Km).
|
km intestine
|
| PBPKO:00336 |
child lifestage |
A lifestage parameter representing individuals typically between 3 and 11 years old.
|
|
| PBPKO:06026 |
unbound venous skin concentration |
The unbound venous concentration of compound in the skin compartment.
|
cvksin_unbound
|
| PBPKO:00312 |
plasma space |
A physiological parameter representing the volume occupied by plasma within a tissue or the body.
|
|
| PBPKO:00038 |
blood flow rate to bone |
A blood flow rate parameter specifically describing the rate to the bone compartment.
|
qbone
|
| PBPKO:00274 |
cumulative amount in urine |
An output parameter representing the total amount of compound excreted in urine over a specific time period.
|
|
| PBPKO:00532 |
blood flow rate to mammary gland |
A blood flow rate parameter specifically describing the rate to the mammary gland compartment.
|
qmam
|
| PBPKO:00528 |
cardiac output rate of plasma |
A blood flow rate parameter representing the cardiac output specifically related to plasma flow.
|
qcplasma
|
| PBPKO:00106 |
fraction of rest body |
A dimensionless fraction of volume defined as the rest of body volume divided per unit of total body weight.
|
frest body
|
| PBPKO:00616 |
concentration of compound in compartment |
An output parameter representing the total concentration of compound in the compartment.
|
|
| PBPKO:00168 |
intestine plasma partition coefficient |
A partition coefficient representing the ratio of compound concentration in intestine to plasma.
|
intestine plasma pc
|
| PBPKO:00636 |
bodily fluid flow rate parameter |
A physiological parameter representing the rate of fluid flow to a particular compartment.
|
|
| PBPKO:03057 |
cell fraction of microsomes |
|
|
| PBPKO:00421 |
fraction of ileum |
A dimensionless fraction of volume defined as the ileum volume divided per unit of total body weight.
|
fileum
|
| PBPKO:00630 |
amount in poorly perfused tissue |
The amount of compound in the poorly perfused tissue compartment.
|
apoorlyperfused
|
| PBPKO:00189 |
catalytic rate constant |
A biochemical parameter quantifying enzymatic reaction velocity (kcat), representing the maximum number of substrate molecules converted per active site per unit time.
|
kcat
|
| PBPKO:04018 |
plasma flow rate to poorly perfused |
A plasma flow rate parameter specifically describing the rate to the poorly perfused compartment.
|
|
| PBPKO:00027 |
fraction of blood flow to kidney |
The dimensionless fraction of cardiac output delivered to the kidney compartment.
|
fqkidney
|
| PBPKO:03043 |
medium other organelles partition coefficient |
|
|
| PBPKO:00129 |
distribution coefficient |
A physicochemical parameter representing the logarithm of the ratio of concentrations of a compound in a mixture of two immiscible phases at equilibrium, specifically describing lipophilicity (LogD).
|
Log D
|
| PBPKO:00149 |
unbound fraction |
A biochemical parameter representing the fraction of a compound that is not bound (e.g., to proteins).
|
FU
|
| PBPKO:04096 |
fraction of urinary tract |
A fraction of volume of compartment defined as the urinary tract volume divided per unit of total body weight.
|
|
| PBPKO:06017 |
unbound concentration in plasma |
The unbound concentration of compound in the plasma compartment.
|
cplasma_unbound
|
| PBPKO:00157 |
fraction unbound heart |
An unbound fraction parameter specifically for the heart compartment.
|
fuheart
|
| PBPKO:04027 |
plasma flow rate to colon |
A plasma flow rate parameter specifically describing the rate to the colon compartment.
|
qcolon_p
|
| PBPKO:00304 |
maximum rate of basolateral transporter in vitro |
Maximum rate (Vmax) of transport via a basolateral transporter, measured in vitro.
|
vmax baso in vitro
|
| PBPKO:03025 |
maximum capacity of binding sites in red cells |
A biochemical parameter representing the total concentration of binding sites available within red blood cells.
|
|
| PBPKO:00104 |
fraction of plasma |
A dimensionless fraction of volume defined as the plasma volume divided per unit of total body weight.
|
fplasma
|
| PBPKO:00499 |
amount in filtrate |
The amount of compound in the filtrate compartment.
|
afiltrate
|
| PBPKO:00573 |
heart blood partition coefficient |
A partition coefficient representing the ratio of compound concentration in the heart to blood.
|
heart blood pc
|
| PBPKO:03008 |
kinetic emptying rate from jejunum lumen to ileum lumen |
A biochemical parameter representing the rate constant of passage of contents from the jejunum segment to the ileum segment.
|
|
| PBPKO:00310 |
influx constant |
A biochemical parameter (kin) describing the rate constant for compound movement into a cell or compartment.
|
kiff
|
| PBPKO:00613 |
maximum rate |
A biochemical parameter representing Vmax of the enzymatic activity
|
|
| PBPKO:00077 |
volume of liver |
A volume parameter representing the total volume of the liver compartment.
|
vliver
|
| PBPKO:00507 |
amount in mammary gland |
The amount of compound in the mammary gland compartment.
|
amam
|
| PBPKO:00647 |
diffusion rate skin |
A diffusion rate parameter representing diffusion rate of the chemical across the skin
|
|
| PBPKO:04031 |
plasma flow rate to gut |
A plasma flow rate parameter specifically describing the rate to the gut compartment.
|
|
| PBPKO:00048 |
blood flow rate to richly perfused |
A blood flow rate parameter specifically describing the rate to the richly perfused organ/tissue compartment.
|
qrichlyperfused
|
| PBPKO:00565 |
blood flow rate to skin stratum corneum exposed |
A blood flow rate to skin parameter specifically describing the rate to the exposed stratum corneum compartment.
|
qskinsce
|
| PBPKO:04024 |
plasma flow rate to duodenum |
A plasma flow rate parameter specifically describing the rate to the duodenum compartment.
|
qduodenum_p
|
| PBPKO:04021 |
plasma flow rate to gall bladder |
A plasma flow rate parameter specifically describing the rate to the gall bladder compartment.
|
|
| PBPKO:00143 |
gastric emptying rate |
A biochemical parameter representing the rate at which the stomach empties its contents into the small intestine.
|
ge
|
| PBPKO:00551 |
PBPK model simulation time |
A parameter representing the time duration over which the model simulation runs.
|
|
| PBPKO:00096 |
fraction of spleen |
A dimensionless fraction of volume defined as the spleen volume divided per unit of total body weight.
|
fspleen
|
| PBPKO:00519 |
tissue plasma partition coefficient |
A partition coefficient representing the ratio of compound concentration in a generic tissue to plasma.
|
kt
|
| PBPKO:00282 |
percentile 2.5 cplasma |
A plasma concentration parameter representing the 2.5th percentile of the plasma concentration distribution in a population simulation.
|
|
| PBPKO:00549 |
concentration in plasma |
The total concentration of compound in the plasma compartment.
|
cplasma, cplasma_total
|
| PBPKO:00240 |
oral exposure |
A route of exposure via the mouth.
|
|
| PBPKO:00060 |
fraction of blood flow to stratum corneum |
The dimensionless fraction of cardiac output delivered to the stratum corneum compartment.
|
scfblood
|
| PBPKO:00434 |
intestinal transit time |
A biochemical parameter representing the time required for a compound to move through the intestine.
|
itt
|
| PBPKO:00258 |
area under curve last |
An area under curve parameter calculated from time zero to the time of the last measurable concentration (AUClast).
|
auclast
|
| PBPKO:00583 |
pancreas blood partition coefficient |
A partition coefficient representing the ratio of compound concentration in the pancreas to blood.
|
pancreas blood pc
|
| PBPKO:00260 |
area under moment curve |
An output parameter calculated as the integral of the product of time and concentration versus time (AUMC).
|
aumc
|
| PBPKO:04066 |
volume of breast |
|
|
| PBPKO:04033 |
plasma flow rate for mass balance |
A plasma flow rate parameter representing the check for total plasma flow mass balance of all the compartments (sum of organ flows should equal cardiac output).
|
qmassbal_p
|
| PBPKO:03064 |
culture medium pH |
|
|
| PBPKO:04055 |
fraction of bile in liver |
A fraction of volume of compartment defined as the volume of bile in the liver divided per unit of total body weight.
|
|
| PBPKO:04013 |
plasma flow rate to skin |
A plasma flow rate parameter specifically describing the rate to the skin compartment.
|
|
| PBPKO:00266 |
mean dissolution time |
An output parameter representing the average time for a compound to dissolve in the body (MDT).
|
MDT
|
| PBPKO:00502 |
amount in plasma |
The amount of compound in the plasma compartment.
|
aplasma
|
| PBPKO:03006 |
fecal excretion rate |
A biochemical parameter representing the allometrically scaled fecal elimination rate constant at which a chemical is eliminated from the body via feces (dependent on species).
|
|
| PBPKO:00527 |
hematocrit volume |
A volume parameter representing the total volume of red blood cells in whole blood.
|
vhct
|
| PBPKO:05003 |
vapor pressure |
A physicochemical parameter describing the vapor pressure of the compound
|
VP
|
| PBPKO:00050 |
blood flow rate to restbody |
A blood flow rate parameter specifically describing the rate to the rest of body compartment (total minus specified organs).
|
qrestbody
|
| PBPKO:00015 |
fraction of blood flow to stomach |
The dimensionless fraction of cardiac output delivered to the stomach compartment.
|
fqstomach
|
| PBPKO:00284 |
tolerable daily intake |
An output parameter (or exposure limit) estimating the amount of a substance that can be ingested daily over a lifetime without appreciable health risk (TDI).
|
tdi
|
| PBPKO:04052 |
surface area of the large intestine lumen |
|
|
| PBPKO:00214 |
Michaelis constant liver |
Michaelis constant representing the substrate concentration at which the reaction rate in the liver is half of Vmax (Km).
|
km liver
|
| PBPKO:00379 |
volume of rest body fetus |
A volume parameter representing the total volume of the rest of body compartment within the fetus.
|
vrest body fetus
|
| PBPKO:00381 |
fetoplacental blood flow rate |
A blood flow rate parameter representing the rate of blood flow between the fetus and the placenta compartment.
|
|
| PBPKO:00107 |
volume of stratum corneum with respect to blood |
A volume parameter representing the total volume of stratum corneum compartment with respect to blood/plasma.
|
scvblood
|
| PBPKO:04064 |
volume of serum |
|
|
| PBPKO:00213 |
maximum rate in liver |
A maximum rate (Vmax) of an enzyme catalysed reaction for a compound in the liver when the enzyme is saturated with substrate.
|
vmax liver
|
| PBPKO:00130 |
dissolution in two phase system |
A physicochemical parameter representing the ratio of a dissolved compound in a two-phase system (often used interchangeably with partition coefficient).
|
|
| PBPKO:00501 |
amount in restbody |
The amount of compound in the rest of the body compartment.
|
arestbody
|
| PBPKO:06012 |
amount in bile |
The amount of chemical in bile.
|
abile
|
| PBPKO:00353 |
cranial cerebrospinal fluid flow rate |
A bodily fluid flow rate parameter representing the flow rate of cerebrospinal fluid (CSF) compartment in the cranial region.
|
|
| PBPKO:03062 |
well depth |
|
|
| PBPKO:00134 |
basic dissociation constant |
A physicochemical parameter representing the negative base-10 logarithm (pKb) of the base dissociation constant (Kb).
|
pKb pK(b) pK(B) affinity constant, Base dissociation constant
|
| PBPKO:00343 |
geriatric lifestage |
A lifestage parameter representing older adults, often considered 60/65 years and older.
|
|
| PBPKO:00524 |
volume of gut |
A volume parameter representing the total volume of the gut compartment.
|
vgut
|
| PBPKO:03040 |
medium lysosomes partition coefficient |
|
|
| PBPKO:00382 |
fetal cardiac output rate |
A blood flow rate parameter representing the volume of blood pumped by the fetal heart compartment per unit time.
|
fco
|
| PBPKO:00039 |
fraction of blood flow to bone |
The dimensionless fraction of cardiac output delivered to the bone compartment.
|
fqbone
|
| PBPKO:04004 |
plasma flow rate to small intestine |
A plasma flow rate parameter specifically describing the rate to the small intestine compartment.
|
|
| PBPKO:04085 |
fraction of thyroid |
A fraction of volume of compartment defined as the thyroid volume divided per unit of total body weight.
|
|
| PBPKO:04079 |
volume of cortical bone |
|
|
| PBPKO:03017 |
Hill coefficient |
A biochemical parameter representing the degree of cooperativity in a multi-site binding interaction.
|
|
| PBPKO:00623 |
amount in blood |
The amount of compound in the blood compartment.
|
ablood
|
| PBPKO:04075 |
volume of skeleton |
|
|
| PBPKO:06020 |
unbound venous brain concentration |
The unbound venous concentration of compound in the brain compartment.
|
cvbrain_unbound
|
| PBPKO:00438 |
concentration in milk |
The total concentration of compound in the milk compartment.
|
cmilk
|
| PBPKO:04042 |
volume of bile |
|
|
| PBPKO:03053 |
cell fraction of lipids |
|
|
| PBPKO:00588 |
skin blood partition coefficient |
A partition coefficient representing the ratio of compound concentration in the skin to blood.
|
skin blood pc
|
| PBPKO:00239 |
route of exposure |
A parameter designating the body part or method through which exposure is introduced.
|
|
| PBPKO:00139 |
biochemical parameter |
A parameter that is compound-dependent and relates to biological interactions or transformations (e.g., clearance, binding, partition coefficients).
|
|
| PBPKO:00042 |
blood flow rate to spleen |
A blood flow rate parameter specifically describing the rate to the spleen compartment.
|
qspleen
|
| PBPKO:00132 |
water solubility |
A physicochemical parameter representing the solubility of a compound specifically in water.
|
|
| PBPKO:00055 |
fraction of blood flow to portal vein |
The dimensionless fraction of cardiac output delivered to the portal vein compartment.
|
fqportalvein
|
| PBPKO:00246 |
intraarterial exposure |
A route of exposure involving administration directly into an artery.
|
|
| PBPKO:03004 |
stomach uptake rate |
The absorption rate constant parameter representing the absorption rate from stomach to gut tissue or any intestine segment
|
k0
|
| PBPKO:04065 |
volume of adrenals |
|
|
| PBPKO:00014 |
blood flow rate to stomach |
A blood flow rate parameter specifically describing the rate to the stomach compartment.
|
qstomach
|
| PBPKO:00391 |
liverfetus plasma partition coefficient |
A partition coefficient representing the ratio of compound concentration in the fetal liver to plasma.
|
liverfetus plasma pc
|
| PBPKO:00646 |
diffusion rate |
A biochemical parameter representing the diffusion rate of the chemical
|
|
| PBPKO:00633 |
amount in alveolar air |
The amount of compound in the alveolar air compartment.
|
aalveolar
|
| PBPKO:00163 |
fraction unbound lung |
An unbound fraction parameter specifically for the lung compartment.
|
fulung
|
| PBPKO:00221 |
degradation rate constant |
A biochemical parameter (kdeg) representing the rate constant for the degradation of a metabolizing enzyme or transporter.
|
kdeg
|
| PBPKO:00427 |
volume of colon |
A volume parameter representing the total volume of the colon compartment.
|
vcolon
|
| PBPKO:04056 |
fraction of feces |
A fraction of volume of compartment defined as the volume of feces divided per unit of total body weight.
|
|
| PBPKO:04019 |
plasma flow rate to richly perfused |
A plasma flow rate parameter specifically describing the rate to the richly perfused compartment.
|
|
| PBPKO:00349 |
cranial cerebrospinal fluid volume |
A volume parameter representing the total volume of cerebrospinal fluid (CSF) compartment in the cranial region.
|
cranial csf volume
|
| PBPKO:00235 |
intrinsic clearance rate |
A clearance rate representing the inherent ability of an organ or tissue to eliminate a compound, independent of blood flow or binding.
|
clint
|
| PBPKO:00538 |
concentration in gut |
The total concentration of compound in the gut compartment.
|
cgut
|
| PBPKO:03031 |
follicle permeability coefficient |
A partition coefficient representing the ability of a substance to pass through the hair follicle structure
|
|
| PBPKO:00078 |
fraction of liver |
A dimensionless fraction of volume defined as the liver volume divided per unit of total body weight.
|
fliver
|
| PBPKO:00083 |
volume of heart |
A volume parameter representing the total volume of the heart compartment.
|
vheart
|
| PBPKO:00640 |
amount in skin stratum corneum of exposed skin |
The amount of chemical in skin stratum corneum of exposed skin
|
askin_sc_e
|
| PBPKO:00409 |
fraction of blood flow to duodenum |
The dimensionless fraction of cardiac output delivered to the duodenum compartment.
|
fqduodenum
|
| PBPKO:00058 |
amount of metabolized |
An output parameter representing the total amount of compound metabolized.
|
ametab
|
| PBPKO:00272 |
amount in urine |
The amount of compound in the urine compartment.
|
aurine
|
| PBPKO:00522 |
volume of filtrate |
A volume parameter representing the total volume of the filtrate compartment.
|
vfiltrate
|
| PBPKO:00176 |
skin plasma partition coefficient |
A partition coefficient representing the ratio of compound concentration in skin to plasma.
|
skin plasma pc
|
| PBPKO:00273 |
amount in feces |
The amount of compound in the feces compartment.
|
afeces
|
| PBPKO:04041 |
volume of small intestine tissue |
|
|
| PBPKO:00437 |
fraction unbound milk |
An unbound fraction parameter specifically for milk.
|
fumilk
|
| PBPKO:00520 |
urinary rate constant |
A biochemical parameter (rate constant) representing the rate at which a compound is cleared via urine, often scaled by body weight.
|
kurine c
|
| PBPKO:04038 |
fraction of blood flow to red blood cells |
A fraction of blood flow to a compartment representing the proportion of total blood flow directed to the erythrocyte volume.
|
|
| PBPKO:00112 |
volume of stratum corneum exposed |
A volume parameter representing the total volume of the exposed stratum corneum compartment.
|
vskin sc e
|
| PBPKO:00161 |
fraction unbound bone |
An unbound fraction parameter specifically for the bone compartment.
|
fubone
|
| PBPKO:03049 |
linear metabolic rate |
|
|
| PBPKO:00592 |
maximum rate of apical transporter |
A maximum rate (Vmax) of an enzyme catalysed reaction for a compound across the apical membrane of an organ when the enzyme is saturated with substrate.
|
Vmax apical
|
| PBPKO:00422 |
fraction of colon |
A dimensionless fraction of volume defined as the colon volume divided per unit of total body weight.
|
fcolon
|
| PBPKO:00222 |
inhibition constant |
A biochemical parameter (Ki) representing the inhibition constant for a specific enzyme or transporter interaction.
|
ki
|
| PBPKO:00650 |
Michaelis |
A flag indicating for Michaelis-Menten or linear metabolism equation being used in the model
|
|
| PBPKO:00585 |
restbody blood partition coefficient |
A partition coefficient representing the ratio of compound concentration in the rest of body compartment to blood.
|
restbody blood pc
|
| PBPKO:03037 |
medium polymer partition coefficient |
|
|
| PBPKO:04044 |
hepatic vein blood flow |
A blood flow rate to compartment representing the flow rate of blood exiting the liver.
|
|
| PBPKO:00254 |
maximum steady state concentration |
An output parameter representing the maximum concentration (Cmax,ss) achieved at steady state during repeated dosing.
|
cmaxss
|
| PBPKO:00255 |
maximum time |
An output parameter representing the time (Tmax) required to reach the peak concentration.
|
tmax
|
| PBPKO:00342 |
pediatric lifestage |
A lifestage parameter representing individuals typically below fifteen years of age.
|
|
| PBPKO:06009 |
amount in lumen |
The amount of chemical in lumen of the intestine.
|
alumen
|
| PBPKO:00054 |
blood flow rate to portal vein |
A blood flow rate parameter specifically describing the rate to the portal vein compartment.
|
qportalvein
|
| PBPKO:00627 |
fraction of arterial plasma volume |
A dimensionless fraction of volume defined as the arterial plasma volume divided per unit of total body weight.
|
farterialplasma
|
| PBPKO:00335 |
toddler lifestage |
A lifestage parameter representing a young child, typically between one and three years old.
|
Tdl
|
| PBPKO:03033 |
partition coeffcient of viable epidermis to blood |
A partition coefficient representing the ratio of chemical concentration in the living skin layers to the blood at equilibrium.;;
|
|
| PBPKO:00572 |
gut blood partition coefficient |
A partition coefficient representing the ratio of compound concentration in the gut to blood.
|
gut blood pc
|
| PBPKO:03041 |
medium intracellular water partition coefficient |
|
|
| PBPKO:00546 |
concentration in skin |
The total concentration of compound in the skin compartment.
|
cksin
|
| PBPKO:00385 |
blood flow rate to brain fetus |
A blood flow rate parameter specifically describing the rate to the fetal brain compartment.
|
qbrainfetus
|
| PBPKO:00046 |
blood flow rate to poorly perfused |
A blood flow rate parameter specifically describing the rate to the poorly perfused organ/tissue compartment.
|
qpoorlyperfused
|
| PBPKO:00167 |
stomach plasma partition coefficient |
A partition coefficient representing the ratio of compound concentration in stomach to plasma.
|
stomach plasma pc
|
| PBPKO:00510 |
fraction of mammary gland |
A dimensionless fraction of volume defined as the mammary gland volume divided per unit of total body weight.
|
fmam
|
| PBPKO:00591 |
fraction unbound plasma |
An unbound fraction parameter specifically for plasma.
|
fuplasma
|
| PBPKO:04010 |
plasma flow rate to heart |
A plasma flow rate parameter specifically describing the rate to the heart compartment.
|
|
| PBPKO:04029 |
plasma flow rate to filtrate |
A plasma flow rate parameter specifically describing the rate to the filtrate compartment.
|
qfiltrate_p
|
| PBPKO:00097 |
volume of lung |
A volume parameter representing the total volume of the lung compartment.
|
vlung
|
| PBPKO:00535 |
resorption maximum |
A biochemical parameter (Tm) representing the maximum rate of tubular resorption (e.g., in the kidney).
|
tmc
|
| PBPKO:00361 |
blood flow rate to cerebrum |
A blood flow rate parameter specifically describing the rate to the cerebrum compartment.
|
qcerebrum
|
| PBPKO:06004 |
amount in stomach |
The amount of chemical in stomach compartment.
|
asto
|
| PBPKO:00017 |
fraction of blood flow to intestine |
The dimensionless fraction of cardiac output delivered to the intestine compartment.
|
fqintestine
|
| PBPKO:00150 |
fraction unbound gut |
An unbound fraction parameter specifically for the gut compartment.
|
fugut
|
| PBPKO:00394 |
restbodyfetus plasma partition coefficient |
A partition coefficient representing the ratio of compound concentration in the fetal rest of body compartment to plasma.
|
restbody plasma pc
|
| PBPKO:06044 |
concentration in ileum |
The concentration of chemical in ileum compartment.
|
ci
|
| PBPKO:00162 |
fraction unbound spleen |
An unbound fraction parameter specifically for the spleen compartment.
|
fuspleen
|
| PBPKO:04095 |
fraction of amniotic fluid |
A fraction of volume of compartment defined as the adrenals volume divided per unit of total body weight.,
A fraction of volume of compartment defined as the amniotic fluid volume divided per unit of total body weight.
|
|
| PBPKO:00094 |
fraction of brain |
A dimensionless fraction of volume defined as the brain volume divided per unit of total body weight.
|
fbrain
|
| PBPKO:03005 |
intrinsic fecal excretion rate |
A biochemical parameter representing the fecal elimination rate constant at which a chemical is eliminated via feces without flow limitations.
|
|
| PBPKO:06057 |
concentration in lysosomes |
|
|
| PBPKO:00311 |
efflux rate constant |
A biochemical parameter (kefflux) describing the rate constant for compound movement out of a cell or compartment.
|
keffluxc
|
| PBPKO:04082 |
fraction of serum |
A fraction of volume of compartment defined as the serum volume divided per unit of total body weight.
|
|
| PBPKO:00056 |
blood flow rate to lymph |
A blood flow rate parameter specifically describing the rate to the lymph compartment.
|
qlymph
|
| PBPKO:00579 |
lung blood partition coefficient |
A partition coefficient representing the ratio of compound concentration in the lung to blood.
|
lung blood pc
|
| PBPKO:00105 |
volume of rest body |
A volume parameter representing the total volume of the rest of body compartment.
|
vrest body
|
| PBPKO:04087 |
fraction of small intestinal lumen |
A fraction of volume of compartment defined as the small intestinal lumen volume divided per unit of total body weight.
|
|
| PBPKO:00012 |
blood flow rate to compartment |
A bodily fluid flow rate parameter representing the rate of blood flow in different parts of the body
|
Q
|
| PBPKO:00624 |
fraction unbound restbody |
An unbound fraction parameter specifically for the rest of the body compartment.
|
furestbody
|
| PBPKO:00026 |
blood flow rate to kidney |
A blood flow rate parameter specifically describing the rate to the kidney compartment.
|
qkidney
|
| PBPKO:00174 |
fat plasma partition coefficient |
A partition coefficient representing the ratio of compound concentration in fat (adipose tissue) to plasma.
|
fat plasma pc,
k_fat_plasma
|
| PBPKO:00261 |
mean residence time |
An output parameter representing the average time a compound resides in the body (MRT).
|
MRT
|
| PBPKO:00275 |
cumulative amount in feces |
An output parameter representing the total amount of compound excreted in feces over a specific time period.
|
|
| PBPKO:06059 |
concentration in intracellular water |
|
|
| PBPKO:00567 |
bone blood partition coefficient |
A partition coefficient representing the ratio of compound concentration in bone to blood.
|
bone blood pc
|
| PBPKO:00412 |
fraction of blood flow to colon |
The dimensionless fraction of cardiac output delivered to the colon compartment.
|
fqcolon
|
| PBPKO:00172 |
muscle plasma partition coefficient |
A partition coefficient representing the ratio of compound concentration in muscle to plasma.
|
muscle plasma pc
|
| PBPKO:00571 |
gonad blood partition coefficient |
A partition coefficient representing the ratio of compound concentration in gonads to blood.
|
gonad blood pc
|
| PBPKO:00368 |
apparent permeability cerebellum to rest of brain |
Apparent permeability of a compound specifically between the cerebellum and the rest of the brain.
|
papp cerebellum brain
|
| PBPKO:00645 |
fat blood partition coefficient |
A partition coefficient representing the ratio of compound concentration in fat to blood.
|
fat blood pc
PCFat
|
| PBPKO:00548 |
concentration in restbody |
The total concentration of compound in the rest of body compartment.
|
crestbody
|
| PBPKO:00350 |
brain mass |
A physiological parameter representing the mass of the brain.
|
|
| PBPKO:06039 |
total venous mammary gland concentration |
The total venous concentration of compound in the mammary gland compartment.
|
cvmam
|
| PBPKO:06050 |
concentration in feces |
The concentration of chemical in feces.
|
cfeces
|
| PBPKO:06053 |
amount in follicles |
An amount of compound in compartment representing the mass of chemical within the hair follicles.
|
|
| PBPKO:04057 |
volume fraction of blood |
|
|
| PBPKO:04100 |
hepatic arterial blood flow |
A blood flow rate to compartment representing the flow rate of blood entering the liver via the artery.
|
|
| PBPKO:00002 |
parameter |
A data item involved in PBPK modelling.
|
|
| PBPKO:00242 |
inhalation exposure |
A route of exposure via inhalation into the lungs.
|
|
| PBPKO:06056 |
concentration in mitochondria |
|
|
| PBPKO:04005 |
plasma flow rate to large intestine |
A plasma flow rate parameter specifically describing the rate to the large intestine compartment.
|
|
| PBPKO:04071 |
volume of stomach lumen |
|
|
| PBPKO:00358 |
volume of cerebellum |
A volume parameter representing the total volume of the cerebellum compartment.
|
vcerebellum
|
| PBPKO:06007 |
amount in ileum |
The amount of chemical in ileum compartment.
|
ai
|
| PBPKO:06010 |
amount in small intestine segment |
The amount of chemical in segment of small intestine.
|
asi_segment
|
| PBPKO:00057 |
fraction of blood flow to lymph |
The dimensionless fraction of cardiac output delivered to the lymph compartment.
|
fqlymph
|
| PBPKO:00631 |
amount in arterial blood |
The amount of compound in the arterial blood compartment.
|
aarterialblood
|
| PBPKO:00332 |
lifestage |
A physiological parameter representing distinct phases of an individual's life (e.g., infant, adult, geriatric).
|
|
| PBPKO:00440 |
phmilk |
A biochemical parameter representing the pH of milk.
|
|
| PBPKO:06011 |
amount in colon |
The amount of chemical in colon compartment.
|
acolon
|
| PBPKO:00315 |
effective permeability |
A biochemical parameter (Peff) representing the rate at which a compound passes through a biological barrier (e.g., intestinal wall).
|
peff
|
| PBPKO:00231 |
sweat clearance rate |
A clearance rate specifically quantifying elimination via sweat.
|
|
| PBPKO:00023 |
fraction of blood flow to pancreas |
The dimensionless fraction of cardiac output delivered to the pancreas compartment.
|
fqpancreas
|
| PBPKO:06038 |
total venous skin concentration |
The total venous concentration of compound in the skin compartment.
|
cvksin
|
| PBPKO:00285 |
reconstructed exposure |
An output parameter estimating the amount of compound exposure based on internal body measurements.
|
|
| PBPKO:00232 |
urinary clearance rate |
A clearance rate specifically quantifying elimination via urine.
|
|
| PBPKO:06041 |
concentration in stomach |
The concentration of chemical in stomach compartment.
|
csto
|
| PBPKO:04003 |
plasma flow rate to intestine |
A plasma flow rate parameter specifically describing the rate to the intestine compartment.
|
|
| PBPKO:03051 |
cell replication time |
|
|
| PBPKO:03054 |
cell fraction of intracellular water |
|
|
| PBPKO:00280 |
max organ concentration |
An output parameter representing the maximum concentration of a compound in a specific organ after exposure.
|
|
| PBPKO:00545 |
concentration in bone marrow |
The total concentration of compound in the bone marrow compartment.
|
cbm
|
| PBPKO:00355 |
volume of hippocampus |
A volume parameter representing the total volume of the hippocampus compartment.
|
vhippocampus
|
| PBPKO:00366 |
frontalcortex brain partition coefficient |
A partition coefficient representing the ratio of compound concentration in the frontal cortex to the overall brain.
|
frontalcortex brain pc
|
| PBPKO:00533 |
blood flow rate for mass balance |
A blood flow rate parameter representing the check for total blood flow mass balance of all the compartments (sum of organ flows should equal cardiac output).
|
qmassbal
|
| PBPKO:03048 |
maximum metabolic rate |
|
|
| PBPKO:00390 |
amniotic transfer coefficient |
A biochemical parameter representing the rate at which a compound transfers from maternal circulation to amniotic fluid.
|
atc
|
| PBPKO:03010 |
kinetic absorption rate from jejunum lumen to intestinal tissue |
A biochemical parameter representing the rate constant at which a chemical moves from the jejunal lumen into the intestinal tissue.
|
|
| PBPKO:00436 |
milk plasma ratio |
A biochemical parameter representing the ratio of compound concentration in milk to plasma.
|
|
| PBPKO:00497 |
amount in liver |
The amount of compound in the liver compartment.
|
aliver
|
| PBPKO:06033 |
total venous brain concentration |
The total venous concentration of compound in the brain compartment.
|
cvbrain
|
| PBPKO:04047 |
diameter of the jejunum lumen |
|
|
| PBPKO:00387 |
gestational age |
A physiological parameter representing the age of a pregnancy, typically measured in weeks.
|
ga
|
| PBPKO:00216 |
dissociation constant |
A biochemical parameter (Kd) measuring the affinity of a compound for its binding partner (e.g., receptor, protein).
|
kd
|
| PBPKO:04016 |
plasma flow rate to spleen |
A plasma flow rate parameter specifically describing the rate to the spleen compartment.
|
|
| PBPKO:00072 |
fraction of small intestine |
A dimensionless fraction of volume defined as the small intestine volume divided per unit of total body weight.
|
fsmall intestine
|
| PBPKO:03074 |
fraction unbound in the cell |
|
|
| PBPKO:00287 |
biomonitoring equivalent |
An output parameter representing the concentration of a chemical (or metabolite) in a biological medium consistent with exposure guidance values (BE).
|
be
|
| PBPKO:00074 |
fraction of large intestine |
A dimensionless fraction of volume defined as the large intestine volume divided per unit of total body weight.
|
flarge intestine
|
| PBPKO:00611 |
fraction of blood flow to a compartment |
A physiological parameter representing dimensionless fraction of cardiac output delivered to a compartment.
|
|
| PBPKO:06046 |
concentration in intestinal tissue |
The concentration of chemical in tissue of intestine.
|
cit
|
| PBPKO:00348 |
cerebrospinal fluid volume |
A volume parameter representing the total volume of cerebrospinal fluid (CSF) compartment in the spinal region.
|
spinal csf volume
|
| PBPKO:03012 |
kinetic absorption rate from large intestinal lumen to intestinal tissue |
A biochemical parameter representing the rate constant at which a chemical moves from the colon lumen into the intestinal tissue.
|
|
| PBPKO:00301 |
concentration in blood |
The total concentration of compound in the blood compartment.
|
cblood
|
| PBPKO:00542 |
concentration in filtrate |
The total concentration of compound in the filtrate compartment.
|
cfiltrate
|
| PBPKO:04023 |
plasma flow rate to lymph |
A plasma flow rate parameter specifically describing the rate to the lymph compartment.
|
|
| PBPKO:00159 |
fraction unbound gonad |
An unbound fraction parameter specifically for the gonad compartment.
|
fugonad
|
| PBPKO:00043 |
fraction of blood flow to spleen |
The dimensionless fraction of cardiac output delivered to the spleen compartment.
|
fqspleen
|
| PBPKO:00087 |
volume of gonad |
A volume parameter representing the total volume of the gonad compartment.
|
vgonad
|
| PBPKO:00417 |
blood flow rate to colon |
A blood flow rate parameter specifically describing the rate to the colon compartment.
|
qcolon
|
| PBPKO:00581 |
milk blood partition coefficient |
A partition coefficient representing the ratio of compound concentration in milk to blood.
|
milk blood pc
|